NATURAL SCIENCES
Journal of fundamental
and
applied researches
EFFECTS OF HYDROGEN SULFIDE GAS ON HEMOSTASIS AND POSSIBLE WAYS OF CORRECTION
2017. №1, pp. 67-72
Trizno Nikolay N. - D.Sc. (Medicine), Professor, Astrakhan State Medical University of the Ministry of Health of Russia, 121 Bakinskaya Str., Astrakhan, 414000, Russian Federation, triznon@mail.ru
Teply David L. - D.Sc. (Biology), Professor, Astrakhan State Medical University of the Ministry of Health of Russia, 121 Bakinskaya Str., Astrakhan, 414000, Russian Federation
Golubkina Ekaterina V. - Assistant, Astrakhan State Medical University of the Ministry of Health of Russia, 121 Bakinskaya Str., Astrakhan, 414000, Russian Federation, neiron-2010@mail.ru
Trizno Matvey N. - Ph.D. (Medicine), Associate Professor, Astrakhan State Medical University of the Ministry of Health of Russia, 121 Bakinskaya Str., Astrakhan, 414000, Russian Federation, pakotmnt@gmail.com
Dyukareva O. S. - postgraduate student, Astrakhan State Medical University of the Ministry of Health of Russia, 121 Bakinskaya Str., Astrakhan, 414000, Russian Federation, oksana.dyukareva2011@yandex.ru
Main aim of this research was to find out specificity of response of the hemostatic system and fibrinolysis as a result of inhalation of hydrogen sulfide gas (H2S) during the chronic intoxication and explore the possibility of correcting changes with acetylsalicylic acid. White male rats were used as a intoxication model by placing in a chamber with controlled concentration of hydrogen sulfide gas mixture for 4 hours each day for four months. Acetylsalicylic acid has been used for correction of changes in one of the test groups. As a result we revealed imbalance of hemostatic profile to procoagulant state. The effect of acetylsalicylic acid on the set of parameters of hemostasis and fibrinolysis, hypercoagulable slightly reduce this changes.
Key words: тромбоциты, эндотелий, плазма крови, гемостаз, тромбин, фибринолиз, сероводородсодержащий газ, крысы, ацетилсалициловая кислота, thrombocytes, endothelium, blood plasma, hemostasis, thrombin, fibrinolysis, hydrogen sulfide gas, rats, acetylsalicylic acid