NATURAL SCIENCES
Journal of fundamental
and
applied researches
The influence of intragastric administration of the mud extract on free radical oxidation processes in different tissues of male rats
2015. №1, pp. 51-55
Kasimova Saule K. - Ph.D. (Biology), Associate Professor, Astrakhan State University, 1 Shaumiana Sq., Astrakhan, 414000, Russian Federation, saule_kasimova@mail.ru
Kondratenko Elena I. - D.Sc. (Biology), Professor, Astrakhan State University, 1 Shaumiana Sq., Astrakhan, 414000, Russian Federation, condr70@mail.ru
Lomteva Natalya A. - Ph.D. (Biology), Associate Professor, Head of Chair, Astrakhan State University, 1 Shaumiana Sq., Astrakhan, 414000, Russian Federation, molecula01@yandex.ru
In this paper we studied the effects of intragastric introduction of mud extract of Lake “Karantinnoe” of Astrakhan region on lipid peroxidation in the liver, testes, adrenal glands and kidneys. The aim of this study was to investigate the action of physiologically adequate extract of sulfide-silt therapeutic mud oz.Karantinnoe Astrakhan region administered intragastric on lipid peroxidation of different tissues of male rats. Studies were conducted on 30 male albino rats. The extract of the sulfide-silt therapeutic mud was diluted physiologically and administered rats intragastrically with the probe during 10 days. The level of free radical oxidation was determined by the rate of spontaneous and ascorbate lipid peroxidation and the original content of malondialdehyde (MDA) in liver homogenates, testes, adrenal glands and kidneys. We got antioxidant effect of peloids. The highest antioxidant effect mud extract exerted by reducing free radical oxidation in the liver and kidneys. Courses use peloids activate humoral pathway regulation of physiological functions and increases the antioxidant reserve tissues of various organs and their resistance to free radical oxidation.
Key words: сульфидно-иловая лечебная грязь, свободнорадикальный гомеостаз, перекисное окисление липидов, малоновый диальдегид, пелоид, sulfide-silt mud treatments, free radical homeostasis, lipid peroxidation, malondialdehyde, peloid