NATURAL SCIENCES

Journal of fundamental
and
applied researches

The effect of sulfide-silt therapeutic mud on free radical skin homeostasis

2012. №4, pp. 73-77

Kasimova Saule K. - Ph.D. (Biology), Associate Professor, Astrakhan State University, 1 Shaumian Sq., Astrakhan, 414000, Russian Federation, saule_kasimova@mail.ru

Kondratenko Yelena I. - D.Sc. (Biology), Professor, Astrakhan State University, 1 Shaumian Sq., Astrakhan, 414000, Russian Federation, condr70@mail.ru

Stepanova Anna V. - undergraduate student, Astrakhan State University, 1 Shaumian Sq., Astrakhan, 414000, Russian Federation, estnauki2009@rambler.ru

The article delves in depth into the problems of preserving and restoring aesthetic health, noting the success of the balneotherapy and peloidotherapy methods in resolving this issue. It has also studied, although less thoroughly, the influence of sulfide silt mud applications on the structure and functional parameters of healthy skin. The research aims to assess the pro- and anti-oxidant balance in the skin model of female rats when faced with conditions of sulfide silt mud contact. This is relevant also as a factor in evaluating the direct effect of biomineral component sulfide silt mud on free radical processes in the skin, and in comparing plasma levels. Previous details relating to the effect of sulfide-silt mud on free radical homeostasis of the skin of 20 females albino rats were used in this work. Some of the applications were applied within 10 days (daily dose), using a 15-minute impact duration. Following decapitation of the rats used in the experiment, the interscapular region of their skin was sampled. The results gave the content of TBA-active products, oxidative modification of proteins, catalase and SOD activity in the skin homogenate and in the blood plasma. It was found that mud applications did not significantly change during lipid peroxidation. Although mud applications did increase the rate of oxidative protein modification in homogenates of the skin, no similar effect occurred in the plasma. Both catalase activity and SOD activity in the skin and in the blood plasma increased under the influence of mud application. This boosted activity of the protective enzyme system contributes to the process of lipid peroxidation in the cells but at relatively harmless levels. The research suggests that this may be a way of adapting and potentiating the transition and homeostatic regulatory systems of the body to a new level of metabolism.

Key words: sulfide-silt mud,free radical homeostasis,oxidative modification of proteins