NATURAL SCIENCES
Journal of fundamental
and
applied researches
Processes of free radical oxidation in pathogenesisof non-developing pregnancy
2013. №4, pp. 72-77
Tishkova Olga G. - post-graduate student, Astrakhan State Medical Academy, Bakinskaya Str., 126, Astrakhan, 414000, Russian Federation, tishkov2003@mail.ru
Dikareva Lyudmila V. - D.Sc. (Medicine), Head of Chair, Astrakhan State Medical Academy, Bakinskaya Str., 126, Astrakhan, 414000, Russian Federation, dikarevalv@mail.ru
Teply David L. - D.Sc. (Biology), Professor, Astrakhan State University, 1 Shaumyan Sq., Astrakhan, 414000, Russian Federation, dima.tepliy@yandex.ru
Teply Dmitriy D. - Ph.D. (Biology), Senior Research Worker, Astrakhan State University, 1 Shaumyan Sq., Astrakhan, 414000, Russian Federation, dima.tepliy@yandex.ru
Belyavskaya Svetlana A. - Doctor, octor, Alexandro-Mariinskaya Regional Hospital, 2 Tatishchev Str., Astrakhan, 414007, Russian Federation, sbelyavskaya74@bk.ru
The aim of this research is to study the level of the products of free radical oxidation of malondialdehyde and protein carbonyl groups in aspiration fluid from the uterus and in peripheral blood from the uterus in patients with progressive and non-developing pregnancy. We studied indices of products of free radical oxidation in the I trimester of pregnancy in 60 women from which we formed two groups: the basic one – 30 women with non-developing pregnancy, the control one – 30 women with physiological pregnancy with direction for artificial abortion. The study showed that in the studied groups indices of products of free radical oxidation in aspiration fluid are significantly higher than that in the peripheral blood , it indicates about their negative influence on the pregnancy outcome. The data from the study showed informative value of indices of free radical oxidation for evaluation of local homeostasis, the possibility of their use in monitoring of the effectiveness of treatment and rehabilitation of patients after non-developing pregnancy.
Key words: non-developing pregnancy,malondialdehyde,carbonyl groups of proteins