THE EFFECT OF HYPOPARATHYROIDISM PREGNANT ON THE AGE DYNAMICS OF THEIR OFFSPRING IN POSTNATAL ONTOGENESIS

Kobzeva, Marina Valerievna  -  lecturer, Stavropol basic medical College, Russian Federation, 355031, Stavropol, St. Serova, 279, kobzeva-78@mail.ru

Dzhandarova Tamara Ismailovna  -  doctor of biological Sciences, Associate Professor, Head of the Department of Anatomy and Physiology, North-Caucasian Federal University, Russian Federation, 355009, Stavropol, St. Pushkina, 1, bldg. 23, tdzhandarova@ncfu.ru

The paper presents the results of an experimental study of the effect of hypoparathyroidism mothers during pregnancy on the age dynamics of the level of progesterone in the blood of her offspring in postnatal ontogenesis. The studies were performed in the offspring of rats, prenatal development which proceeded on the background of hypoparathyroidism mother in the 1st, 7th, 30th, 90th and 180th days after birth. Deficiency of parathyroid hormone in animals of the parent generation created by removal of parathyroid glands using high-frequency electrosurgical device (EH-30) in the mode of coagulation. Controls were the descendants of the intact rats of the respective age periods of ontogenesis. All rats were determined the content of progesterone in the blood. It used a set of reagents DRG (Germany) and microstrip photometer for immune analysis, "STAT FAX 303 Plus". It was found that the offspring, prenatal development which proceeded on the background of hypoparathyroidism mothers in the first days after birth the level of progesterone in the blood were significantly higher, and in subsequent periods of ontogeny is significantly low compared to similar data from the descendants of the control rats. This, of course, can affect the development of not only the reproductive system but also the embryonic development of the brain.

Key words: hypoparathyroidism, maternal generation, pregnancy, progesterone, offspring, prenatal development, postnatal period of ontogenesis, age dynamics, hypocalcemia.