STUDYING THE INFLUENCE OF "SOCIAL" STRESS AND SCUTELLARIA BAICALENSIS GEORGI EXTRACT ON THE DEVELOPMENT OF A CONDITIONED REFLEX OF PASSIVE AVOIDANCE

Uranova Valeria V.  -  assistant of the department of chemistry of Pharmacy faculty, Astrakhan State Medical University, Russia, 414000, Astrakhan, Bakinskaya st., fibi_cool@list.ru

Lomteva Natalya Arkadyevna  -  Doctor of Biological Sciences, Associate Professor,, Acting Head of the Department of Physiology, Morphology, Genetics and Biomedicine, Astrakhan State University named by V.N. Tatischev, Russia, 414000, Astrakhan, pl. Shaumyan, 1, physiology-agu@mail.ru

Bliznyak Olga V.  -  student, Astrakhan State Medical University, Russia, 414000, Astrakhan, Bakinskaya st., 121, olhabliznyak@yandex.ru

The study is devoted to the study of the influence of "social" stress and the extract of Scutellaria baicalensis Georgi on the development of a conditioned passive avoidance reflex. Materials and methods. We used an extract obtained by maceration from the underground part of Scutellaria baicalensis Georgi. The study of cognitive processes was carried out on 100 male non-linear rats aged 7-9 months, which were divided into five groups. Modeling of "social" stress in groups was carried out by developing inter-male confrontations under conditions of paired sensory contact. Cognitive functions were analyzed using a standard passive avoidance conditioned reflex setting. The results of the study indicate the ability of the extract of Scutellaria baicalensis Georgi to have a leveling effect during the development of stress, significantly reducing its negative effect, which manifests itself in the deterioration of the memorization and reproduction of CPAR to a greater extent for animals with an aggressive type of behavior. Conclusion. The presence of a smoothed effect of the extract determines the prospects for further detailed study of its biopharmaceutical activity.

Key words: Plant material, Scutellaria baicalensis, Lamiaceae, "social" stress, extract