THE EFFECT OF SEROTONIN ON ERYTHROCYTES REACTIVITY AND HEART RATE REGULATION IN RATS OF DIFFERENT AGES
Alexandrova Julia O. - student, Astrakhan State University named by V.N. Tatischev, 1 Shaumyan Sq., Astrakhan, 414000, Russia, alexandrovayulia2014@yandex.ru
Sultanova Leila R. - student, Astrakhan State University named by V.N. Tatischev, 1 Shaumyan Sq., Astrakhan, 414000, Russia,
Kuryanova Evgenia Vladimirovna - Doctor of Biological Sciences, Associate Professor, Professor of the Department of Fundamental Biology, Astrakhan State University named by V.N. Tatischev, Russia, 414000, Astrakhan, Shaumyan Sq.,1, teplyconf@yandex.ru
Tryasuchev Andrey Valerievich - PhD in Biological sciences, assistant professor of the Department of Physiology, Morphology, Genetics and Biomedicine, Astrakhan State University named by V.N. Tatischev, Russia, 414000, Astrakhan, Shaumyan Sq.,1, fyzevk@rambler.ru
We studied ?-adrenoreactivity of erythrocytes and serotonin-reactivity of erythrocytes (?-ARE and SRE) and heart rate variability (HRV) in pubertal (5-6 months) and old (20-24 months) nonlinear rat males in the initial state and after 3 days injection of serotonin (200 mcg/kg intraperitoneally). It was found that in the initial state, the degree of decrease in the intensity of osmotic hemolysis of erythrocytes in the presence of the beta-adrenergic receptor blocker anapriline or ?-ARE is 70-77 rel. units, in the presence of the serotonin receptor blocker promethazine or SRE - 50-65 rel. units. In rats of different ages, ?-ARE and SRE do not differ significantly, but SRE in old animals is somewhat higher than in pubertal animals. The heart rate and the main ones showed HRV in pubertal and old male rats do not differ significantly, but old animals have a slightly lower power of HRV spectrum waves than pubertal ones. The introduction of serotonin in pubertal animals is accompanied by a decrease in ?-ARE and SRE, an increase in heart rate and an increase in heart rate variability in the LF and HF ranges. In old animals, the administration of serotonin slightly changes ?-ARE and SRE, which remain high, but contributes to a decrease in heart rate and heart rate variability in the LF- and HF-ranges. The results indicate a weakening or change in the response to serotonin with aging. The reasons for this may be an age-related decrease in the rate of adaptive restructuring of cellular serotonin reception, a decrease in the power of regulatory influences through the parasympathetic regulation channel, the activity of which is modulated by serotonergic mechanisms. The revealed differences provide a basis for a more careful study of the response to exogenous serotonin and the participation of this monoamine in regulatory processes during aging.
Key words: serotonin, adrenoreactivity of erythrocytes, serotonin-reactivity of erythrocytes, anapriline, promethazine, heart rate variability, pubertal and old rats
