KALMYKIA IN MODELING EXPERIMENTAL ULCEROGENESIS IN RATS

Badmaeva Saglar Evgenievna  -  PhD of Biological Sciences, Associate Professor of the Department of general biology and physiology, “Kalmyk State University named after B. B. Gorodovikov”, Russia, Republic of Kalmykia, Elista, Pushkin street, 11, badmaevase80@gmail.com

Alenikova Darya Vladimirovna  -  master's student of the Department of general biology and physiology, “Kalmyk State University named after B. B. Gorodovikov”, Russia, Republic of Kalmykia, Elista, Pushkin street, 11, dasha.alenikova@gmail.com

Edlyaeva Gilyana Menkenovna  -  master's student of the Department of general biology and physiology, “Kalmyk State University named after B. B. Gorodovikov”, Russia, Republic of Kalmykia, Elista, Pushkin street, edlyaeva1997@gmail.com

On the territory of the Republic of Kalmykia there are significant reserves of natural curative mineral waters, which are practically not used balneologically. Special attention is attracted by the mineral waters of the Har-Buluk and Kislyj deposits, which are actively used by the local population for the treatment of different diseases of a wide profile, including inflammatory diseases of the gastrointestinal tract. However, until recently, no comprehensive scientific research that substantiates the prospects of medical and biological development of these mineral waters has been carried out. In our studies, using three experimental models of ulceration - stress, ligation of the pylorus and ethanol, the protective antiulcer properties of the two mineral water deposits, Har-Buluk and Kislyj, were studied. It was shown that the mineral waters of these two deposits significantly increase the resistance of the gastric mucosa to the influence of various ulcerogenic factors, preventing the development of gastric ulcers.

Key words: mineral waters of Kalmykia, ethanol ulcers, stress ulcers, gastric mucosa, pylorus ligation, peripheral and central mechanisms of ulcerogenesis