REVIEW OF ANTIOXIDANT ACTIVITY OF FLAVONOIDS OF PLANT RAW MATERIALS OF THE GENUS SCUTELLARIA

Uranova Valeria V.  -  assistant of the department of chemistry of Pharmacy faculty, Astrakhan State Medical University, Russia, 414000, Astrakhan, Bakinskaya st., fibi_cool@list.ru

Lomteva Natalya Arkadyevna  -  Doctor of Biological Sciences, Associate Professor,, Acting Head of the Department of Physiology, Morphology, Genetics and Biomedicine, Astrakhan State University named by V.N. Tatischev, Russia, 414000, Astrakhan, pl. Shaumyan, 1, physiology-agu@mail.ru

Bliznyak Olga V.  -  student, Astrakhan State Medical University, Russia, 414000, Astrakhan, Bakinskaya st., 121, olhabliznyak@yandex.ru

This work provides an overview of the antioxidant activity of flavonoids from plant materials of the genus Scutellaria. The use of preparations based on medicinal plants containing flavonoids helps protect the body from reactive oxygen species (ROS), which aggressively act on cells and cause changes in cell membranes. The antioxidant action of flavonoids is realized as a result of inhibition of the formed ROS molecules or by reducing the activity of the enzyme composition that inhibits the action of ROS. Flavonoids are reducing agents of peroxyl radicals, therefore, they are quite effective in inhibiting lipid peroxidation. The main substances with high antioxidant activity are baicalin, beykalein and wagonin. Their action is based on the phenomena of absorption of peroxynitrite (ONOO-) and inhibition of ONOO-mediated formation of nitrotyrosine. In the course of the study, it was revealed that representatives of the genus Scutellaria actively inhibit oxidative processes in the cells of the body, which leads to the formation of antioxidant protection under conditions of oxidative stress.

Key words: Flavonoids, antioxidant activity, plant materials, Lamiaceae family, Scutellaria genus, Scutellaria baicalensis, Scutellaria galericulata, reactive oxygen species.