REACTION OF THE ENZYMATIC COMPONENT OF THE ANTIOXIDANT SYSTEM OF LUNG TISSUE TO EXOGENOUS HYPERTHERMIA IN RATS OF DIFFERENT AGES

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Ryabykina Natalia V.  -  Cand. Sci. (Biol.), Associate Professor of the Department, Astrakhan State University, Shaumyan Sq., 1, Astrakhan, 414056, Russia, tel.: (8512) 24-66-58, knv0911@mail.ru

The comparative analysis of activity of an enzymatic link of antioxidant system, with a simultaneous assessment of level of accumulation of termination and intermediate products of free-radical oxidation in pulmonary tissue of rats of different postnatal age in the conditions of acute hyperthermia. Age features in activity of a superoxide dismutase, catalase, intensity of formation of diene conjugates, hydroperoxides of lipids, a malondialdehyde and intensity of peroxide modification of proteins in pulmonary tissue of 6-week, 5-, 12-and 30-month-old white rats are revealed. At a thermal tension multidirectional changes in activity of a catalase and superoxide dismutase and various expressiveness of intensity of free-radical processes in pulmonary tissue of animals of different ages are shown. The results show greater enzymatic activity of antioxidants and light stress reactivity of the lungs against free radical processes predominantly in young rats.

Key words: lungs, age, superoxide-dismutase, catalase, free radical oxidation of lipids and proteins, heat stress