PHARMACOLOGICAL CORRECTION OF APOPTOSIS OF WHITE BLOOD ELEMENTS AND FREE RADICAL PROCESSES UNDER THE INFLUENCE OF STRESS AT DIFFERENT STAGES OF ONTOGENESIS IN MALE RATS
Vershinina Natalya Valerievna - Candidate of Biological Sciences, Associate Professor of the Department of Fundamental Biology, Astrakhan State University named by V.N. Tatischev, Russia, 414000, Astrakhan, Shaumyan Sq. 1,
Cherkesova Dilara Ulubievna - Doctor of Biological Sciences, Associate Professor, Professor of the Department of Physiology, Federal State Budgetary Educational Institution of Higher Education "Dagestan State University", Russia 367000, Makhachkala, Magomet Gadzhiev st., 41, cher2005@mail.ru
Kovalenko Natalya Vyacheslavovna - assistent, Federal State Budgetary Educational Institution of Higher Education “Astrakhan State University named by V.N. Tatishchev", Russia, 414056, Astrakhan, Tatischev st., 20a,
Ashyrov Mekangeldi - student, Federal State Budgetary Educational Institution of Higher Education “Astrakhan State University named by V.N. Tatishchev", Russia, 414056, Astrakhan, Tatischev st., 20a,
Amanov Nurgeldi - student, Federal State Budgetary Educational Institution of Higher Education “Astrakhan State University named by V.N. Tatishchev", Russia, 414056, Astrakhan, Tatischev st., 20a,
The functional relationship of apoptosis of blood leukocytes and free radical processes under the action of hypohydration stress and antioxidants in male rats at different stages of ontogenesis was investigated. Hypohydration stress caused a sharp increase in the level of neutrophil and lymphocyte apoptosis in young and old rats due to an increase in the level of free radical processes. Under the conditions of stress, vitamin C, cycloferon and mexidol reduced the level of lipid peroxidation of blood plasma, as a result, reduced the level of neutrophil and lymphocyte apoptosis, in animals regardless of age compared to the group of stressed not previously treated drugs.
Key words: apoptosis, hypohydration stress, neutrophils, lymphocytes, vitamin C, mexidol, cycloferon, emoxipin, immobilization stress, lipid peroxidation
