EFFECT OF PRENATAL α-TOCOPHEROL ON THE BEHAVIOR AND FREE RADICAL HOMEOSTASIS OF DIFFERENT PARTS OF THE CNS OF MATURE MALE RATS

Kuleshova Olga N.  -  Ph. D. (Biology), Senior Researcher, Astrakhan State University, 1 Shaumyana Sq., Astrakhan, 414000, Russian Federation, pozdniakova_olga@list.ru

Teply Dmitry D.  -  Ph.D. (Biology), Senior Researcher, Astrakhan State University, Russia, 414000, Astrakhan, Shaumyan Sq.,1, , dima.tepliy@yandex.ru

In connection with the wide range of effects of α-tocopherol on the organism and the ongoing debate in the literature about the feasibility of its use during pregnancy, we considered the effect of maternal α-tocopherol on the behavior and free radical homeostasis in the CNS tissues of their sexually mature offspring. The experiment involved 16 primiparous females of mongrel white rats, who, starting from the 2nd day of pregnancy, orally received an oil solution of α-tocopherol at the rate of 1 mg / 100 g of body weight, the control group received appropriate doses of refined sunflower oil. In their male offspring at the age of 90 days, behavioral responses in the Suok-test and changes in free radical homeostasis in the tissues of the cerebral cortex, cerebellum and spinal cord were studied. The research and locomotor component of the behavior of the experimental group increased, and there was no anxiolytic effect. Free radical homeostasis changed depending on the level of the CNS: more significant changes were noted in the underlying parts – in the spinal cord. The most significant modification was made to the activity levels of SOD and OMP: fluctuations of different modality were observed in all the considered departments. Thus, changes in animal behavior are positive, however, the growth of free radical oxidation products and a decrease in SOD activity symbolize an additional load

Key words: α-tocopherol, males, free radical homeostasis, oxidative modification of proteins, superoxide dismutase, lipid peroxidation, antioxidant system