NATURAL SCIENCES

Journal of fundamental
and
applied researches

Histochemical changes of the liver tissue under conditions of chronic alcohol intoxication

2016. №2, pp. 50-55

Lazko Alexey E. - D.Sc. (Med.), Professor, Astrakhan State University, 20a Tatishcheva Str., Astrakhan, 414002, Russian Federation, radmila56@mail.ru

Vovchenko Alexey F - Assistant, Astrakhan State Medical University, 121 Bakinskaya Str., Astrakhan, 414000, Russian Federation, vovchenkoaf@mail.ru

Performed histochemical study of liver tissue in experimental animals with chronic alcohol intoxication. The experiment was carried out on 50 white non-linear mice. Animals alkoholisierung for 3 months polutorapolnymi method, using as the sole liquid source of 20 % ethanol, which is optimal for creating a model of chronic alcoholism. Revealed increased activity of alcohol dehydrogenase in the liver cells. Total activity of succinate dehydrogenase in hepatocytes was reduced as compared with the control. The activity of G-6-FDG in the hepatocytes of animals in comparison with control group presented moderate and small granules of deformazione. It is established that chronic intoxication with ethanol causes disruption of processes of a cellular metabolism in the tissues of the liver, reduced activity of metabolic processes involving oxygen, the standby mechanism of compensation of the energy deficit.

Key words: печень, гепатоциты, хроническая алкогольная интоксикация, гистохимическая активность, алкогольдегидрогеназа, глюкозо-6-фосфатдегидрогеназа, сукцинатдегидрогеназа кислая и щелочная фосфатаза, неспецифические эстеразы, liver, hepatocytes, chronic alcoholic