NATURAL SCIENCES

Journal of fundamental
and
applied researches

Immunological and metabolic changes in the organism of patients with lepramatous type of the leprosy

2015. №4, pp. 60-62

Shishkina T.A. - Ph.D. (Medicine), Assistant, Astrakhan Medical State University, 121 Bakinskaya Str., Astrakhan, 414024, Russian Federation, suntata@rambler.ru

Naumov A.V. - Assistant, Astrakhan Medical State University, 121 Bakinskaya Str., Astrakhan, 414024, Russian Federation

Polunin I.N. - D.Sc. (Medicine), Professor, Astrakhan Medical State University, 121 Bakinskaya Str., Astrakhan, 414024, Russian Federation

Naumova L.I. - D.Sc. (Medicine), Professor, Astrakhan Medical State University, 121 Bakinskaya Str., Astrakhan, 414024, Russian Federation, suntata@rambler.ru

At the heart of the pathological changes arising in an organism of patients with a leprosy violation of immune function of an organism lies. First of all, it is shown by increase of production of cytokine, especially a tumor necrosis factor-α. At increase of concentration of this cytokine, activity of of Kuppfer’s cells in a liver that leads to repeated increase in pro-inflammatory cytokine increases. Cytokinoemia is followed by damage of structures of a liver and violation of microcirculation to all organism. Injury of a liver reduces its desintoxication function. Violations of microcirculation interfere with adequate regenerator processes.

Key words: лепра, иммунная функция, цитокины, фактор некроза опухоли, печень, клетки Куппфера, нарушение микроциркуляции, leprosy, immune function, cytokine, tumor necrosis factor, liver, Kuppfer's cells, microcirculation violation

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