NATURAL SCIENCES

Journal of fundamental
and
applied researches

Dynamics of free-radical processes in chronic intoxication

2015. №3, pp. 61-65

Rozhkova Irina S. - Ph.D. (Medicine), Associate Professor, Astrakhan State Medical University, 121 Bakinskaya Str., Astrakhan, 414000, Russian Federation, polyris@list.ru

Teply David L. - D.Sc. (Biology), Professor, Astrakhan State University, 1 Shaumyana Sq., Astrakhan, 414000, Russian Federation, dima.tepliy@yandex.ru

The state of free-radical processes in bodies of immune system and the blood plasma of rats with chronic intoxication in ontogeny. In the course of the experiment revealed the age changes in the level of free radical processes in thymus gland, lymph nodes, a spleen and in the blood plasma of rats - males at various stages of ontogeny, revealed differences rate of lipid peroxidation and oxidative modification of proteins. A comparison of the activity of the state of antioxidant protection of immune system and of blood plasma in the ontogenetic aspect. The most intensive lipid peroxidation and protein occur at a young age. Under the experimental conditions set higher levels of antioxidant activity of blood plasma in young and aged rats, in comparison with a group of mature animals.

Key words: свободно-радикальные процессы, онтогенез, плазма крови, крысы, перекисное окисление липидов, окислительная модификация белков, free radical processes, ontogenesis, plasma blood, rats, lipid peroxidation, albumen oxidation modification