NATURAL SCIENCES

Journal of fundamental
and
applied researches

Analysis of polymorphism of IL-4RA and clinicoanamnestic aspects of asthma in children of the Astrakhan region

2014. №4, pp. 71-75

Stroykova Tatiana R. - Ph.D. (Medicine), Associate Professor, Astrakhan State Medical University, 121 Р’akinskaya Str., Astrakhan, 414000, Russian Federation, mega.astor@mail.ru

Bashkina Olga Рђ. - D.Sc. (Medicine), Professor, Head of Chair, Astrakhan State Medical University, 121 Р’akinskaya Str., Astrakhan, 414000, Russian Federation, bashkina1@mail.ru

Sergienko Diana F. - D.Sc. (Medicine), Associate Professor, Astrakhan State Medical University, 121 Р’akinskaya Str., Astrakhan, 414000, Russian Federation, gazken@rambler.ru

Search of the genetic markers controlling key links of pathogenesis of bronchial asthma is actual. The most perspective is identification of association of polymorphic loci of candidate genes with risk of development of heavy forms of bronchial asthma in children. Frequent change of structure of genes is polymorphism of single nucleotides which influence a phenotype of a disease and predetermine distinctions in clinical manifestations of the same nosological form. Studying of pro-motor regions of genes of cytokine and detection of features of functioning of a cytokines network taking into account environmental risk factors of a disease will allow to approach understanding of mechanisms of formation of an uncontrollable course of bronchial asthma at children’s age and to improve preventive actions. IL-4 and its receptor plays the central role in inflammation development. The analysis of genetic regulation of activity of this cytokine is of great importance for understanding of mechanisms of development of asthma. Associations on polymorphism of I50V of a gene of IL-4RA at 177 children of the Astrakhan region are studied. Interrelations of association of genotypes and alleles with severity of asthma are studied.

Key words: астма, дети, полиморфизм гена, генотипы, аллели, цитокины, воспаление, asthma, children, polymorphism of a gene, genotypes, allele, cytokines, inflammation