NATURAL SCIENCES

Journal of fundamental
and
applied researches

Morphofunctional state of reproductive system in white male rats under conditions of food stress

2014. №1, pp. 060-067

Loginov Pavel V. - Ph.D. (Biology),Associate Professor, Astrakhan State Medical Academy, 121 Bakinskaya Str., Astrakhan, 414000, Russian Federation, agma@astranet.ru

Teply David L. - D.Sc. (Biology),Professor, Astrakhan State University, 1 Shaumyan Sq., Astrakhan, 414000, Russian Federation, dima.tepliy@yandex.ru

Nikolaev Aleksandr A. - D.Sc. (Medicine),Professor, Astrakhan State Medical Academy, 121 Bakinskaya Str., Astrakhan, 414000, Russian Federation, agma@astranet.ru

The purpose of the paper is to study effects of deficiency in nutrients on morphofunctional state of different units of reproductive system. White male rats were fed with the special diet during 30 days. Erythrocyte haemolysis increase under experimental conditions allows us to conclude that the oxidative stress development takes place. Under conditions of deficiency in nutrients lipid peroxidation acceleration in testicular and hypothalamic tissues has been found to take place. Relative weights of gonads and pituitary were decreased to the end of experimental influence in accordance with the positive correlation coefficient r = +0.461. The total number of defective epididymal spermatozoa decreased by more than 4.5 times compared to the control. The leading pathologies were broken and lost tails of spermatozoa. In the structure of seminiferous tubules, the features of spermatogenic epithelium necrosis took place on the background of interstitial tissue increase at the expense of small Leydig’s cells. Thus, functional state suppression in testes is connected with lipid peroxidation intensification in the system hypothalamus-pituitary-testes.

Key words: lipid peroxidation, malonic dialdehyde, hypothalamus, testes, epididymal spermatozoa, spermatogenic epithelium, Leydig’s cells