NATURAL SCIENCES

Journal of fundamental
and
applied researches

Features of free radical processes in the organism of white rats with the introduction of phosphorus-containing substances

2018. №1, pp. 44-48

Mokshin D.A. - postgraduate student, Saratov State Agrarian University named after N.I. Vavilov, 1 Teatralnaya Sq., Saratov, 410012, Russian Federation, niko-pudovkin@yandex.ru

Pudovkin N.A. - D.Sc. (Biology), Professor, Saratov State Agrarian University named after N.I. Vavilov, 1 Teatralnaya Sq., Saratov, 410012, Russian Federation, niko-pudovkin@yandex.ru

The paper presents the results of studies on the state of lipid peroxidation and the antioxidant system of protecting the body of white rats with the use of the phosphorus-containing substance butophosphamide, with subcutaneous administration of the compound at a dose of 1 ml (0.1 g for DV) and vitamin B (0.001 g for DV). The experiment was carried out on male white rats. Butophosphamide and vitamin B reduce the concentration of diene conjugates, on day 5 and 10 in the body of white rats by 35.53 % and 18.61 % respectively, relative to control. The concentration of malonic dialdehyde in the tissues of the internal organs of white rats after intramuscular administration of butophosphamide and vitamin B12 on days 5 and 10 is, on average, reduced by 8.5 % - 35.53 % and 7.11 % - 18.61% respectively, relative to the reference values. After the introduction of butophosphamide and vitamin B, all the tissues and organs of white rats studied in the increase in catalase activity are arranged in the following order: brain > serum > stomach > large intestine > small intestine > heart > skeletal muscles > lungs > kidneys > liver. It has been established that butophosphamide and vitamin B12 do not cause a malfunction in the processes of lipid peroxidation and the antioxidant system of the body of white rats.

Key words: бутофосфан, свободнорадикальное окисление, малоновый диальдегид, диеновые конъюгаты, каталаза, белые крысы, антиоксидантная система, витамин B, butophosphane, free radical oxidation, malonic dialdehyde, diene conjugates, catalase, white rats, antioxidant